Dexrazoxane used with doxorubicin

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WebFeb 17, 2024 · Dosing: Pediatric. Prevention of anthracycline cardiomyopathy associated with acute lymphoblastic leukemia (ALL): Limited data available: Infants, Children, and Adolescents: IV: A 10:1 dose ratio of dexrazoxane:doxorubicin (example: 300 mg/m 2 dexrazoxane: 30 mg/m 2 doxorubicin) (Lipshultz 2010; Moghrabi 2007; Silverman 2010). WebIn a meta-analysis of six randomized trials, of which only three examined dexrazoxane use in a homogenous breast cancer population receiving initial anthracycline-based therapy, dexrazoxane given with either doxorubicin or epirubicin significantly reduced the incidence of clinical and subclinical cardiotoxicity.

Zinecard (dexrazoxane for injection) - Food and Drug …

WebAug 22, 2024 · Administer in a dosage ratio relative to the IV dose of doxorubicin hydrochloride. Adults Prophylaxis of Anthracycline-induced Cardiomyopathy IV. Recommended dosage ratio of dexrazoxane to doxorubicin is 10:1 (e.g., 500 mg/m 2 dexrazoxane should be administered with 50 mg/m 2 doxorubicin). Prescribing Limits … WebThere is some evidence that the use of dexrazoxane concurrently with the initiation of fluorouracil, doxorubicin, and cyclophosphamide (FAC) therapy interferes with the antitumor efficacy of the regimen, and this use is not recommended. ... The recommended dosage ratio of ZINECARD:doxorubicin is 10:1 (e.g., 500 mg/m2 ZINECARD:50 mg/m2 ... citizens advice sunbury on thames

Upfront dexrazoxane for the reduction of anthracycline

WebThe recommended dexrazoxane : doxorubicin (or epirubicin) dosage ratio is 10 : 1 (e.g., if 40 mg/m 2 of doxorubicin is used, 400 mg/m 2 of dexrazoxane should be administered). A reconstituted dexrazoxane solution should be administered intravenously by slow push starting 15 to 30 minutes before intravenous administration of anthracycline. WebDexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications. Heart damage limits the length of time you can be ... WebSummary. Dexrazoxane is a cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. Brand Names. Savene, Totect, Zinecard. Generic Name. Dexrazoxane. DrugBank Accession Number. DB00380. citizens advice stroud and cotswold

Dexrazoxane Injection: MedlinePlus Drug Information

Totect (dexrazoxane) Uses, Dosage, Side Effects - Drugs.com

WebDexrazoxane is the generic name for the trade name drug Zinecard. In some cases, health care professionals may use the trade name Zinecard when referring to the generic drug … WebJan 12, 2024 · The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an … citizens advice sunderland facebookWebZinecard ® (dexrazoxane for injection) DESCRIPTION ZINECARD ® (dexrazoxane for injection) is a sterile, pyrogen-free lyophilizate intended for intravenous administration. It … dick clark r

"WebDexrazoxane hydrochloride is approved to treat severe side effects caused by certain types of chemotherapy. It is used to treat the following: Cardiac (heart) side effects caused by … " - Dexrazoxane used with doxorubicin

Dexrazoxane used with doxorubicin

Upfront dexrazoxane for the reduction of anthracycline …

WebCardioprotection for 20 Years for Children With Cancer “Dexrazoxane (Totect, Zinecard) provides long-term cardioprotection for children treated with doxorubicin for cancer, and its co-administration with doxorubicin should be standard of care, say researchers in a report publishedpublished January 20 in the Journal of Clinical Oncology… Underused in Children WebApr 10, 2024 · The initial cumul ative doses of doxorubicin used in oste-osarcoma were high, exceeding 450 mg/m. 2. These doses. ... Dexrazoxane has been used in comb ination of doxorubi-cin to prevent heart ...

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WebDexrazoxane has been used in combination of doxorubicin to prevent heart failure. Schwartz et al used dexrazoxane as a cardioprotection to enable the use of higher cumulative dose of doxorubicin in children with osteosarcoma, cumulative dose of doxorubicin of 450 to 600 mg/m 2 was used. Out of 242 patients, only 5 developed … WebCOMMON BRAND NAME (S): Zinecard. USES: Dexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer …

WebAug 31, 2024 · Dexrazoxane for injection, a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate intended for intravenous administration. Chemically, dexrazoxane is (S)-4,4'- (1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione. The structural formula is as follows: WebApr 11, 2024 · Prolonged local delivery of doxorubicin to cancer cells using lipid liquid crystalline system. Author links open overlay panel Malihe Karimi a 1 ... is used to dissolve the amphiphilic moieties and tween 80 is usually used to produce a homogenized vehicle solution and to modify the release pattern of the loaded drug. NMP is an FDA approved …

WebDexrazoxane is clinically used to reduce doxorubicin cardiotoxicity and anthracycline-induced extravasation injury. Dexrazoxane is a strong catalytic inhibitor of topoisomerase II. It can also undergo metabolism to form an iron-binding analog of EDTA. Dexrazoxane was originally thought to act by red … WebAug 16, 2024 · The suggested dosage ratio of dexrazoxane to doxorubicin is 10 to 1 (e.g., 500 mg/m^2 dexrazoxane to 50 mg/m^2 doxorubicin). It is advisable to give dexrazoxane before doxorubicin. ... The common side effects that culminate from dexrazoxane use include dose-limiting myelotoxicity (neutropenia, leukopenia, granulocytopenia, and …

WebDoxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used together with other chemotherapy agents. Doxorubicin is given by injection into a vein.. Common side …

WebAvoid concurrent use of doxorubicin HCl with inhibitors and inducers of CYP3A4, CYP2D6, and/or P-gp (7.1). ... In adults, consider administration of dexrazoxane [see Warnings and Precautions (5.3)]. Incompatibility with Other Drugs . Do not admix doxorubicin HCl with other drugs. If doxorubicin HCl is mixed with heparin or dick clark rockin newWebFor doxorubicin, use of dexrazoxane is recommended after the cumulative dose reaches 300 mg/m2 (i.e., 55% of the recommended maximum). A similar formula could be used for epirubicin, that is, institution of dexrazoxane when the cumulative dose of epirubicin reaches 550 mg/m2, as the recommended maximum cumulative dose in Canada is 1000 … citizens advice sunderlandWebdexrazoxane for cardiomyopathy, reduce the Totect dosage proportionately (maintaining the 10:1 ratio) in patients with hepatic impairment, since a doxorubicin dose reduction is … dick clark realty delphos ohWebHowever, cardiotoxicity is one of the life-threatening side effects of doxorubicin-based therapy. Dexrazoxane (Zinecard, also known as … citizens advice sunderland tyne and wearWebAug 16, 2024 · Dexrazoxane is a medication used in the management and treatment of anthracycline-induced cardiotoxicity and extravasation injuries. It is in the class of medications known as cardioprotectants. ... The … citizens advice sunderland numberWebJul 18, 2024 · Dexrazoxane for injection is a cytoprotective agent indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m 2 and who will continue to receive doxorubicin therapy to maintain tumor … dick clark rockinWebJul 15, 2024 · Abstract. Doxorubicin cardiac toxicity is widely misunderstood, largely preventable, and starts with the first dose. This article reviews the history of doxorubicin cardiac toxicity and strategies … dick clark rockin eve 2021