WebAug 5, 2024 · After vortex mixing for 5 s, 50 µL of the IS stock (100 ng/mL) and 300 µL methanol were added (again vortexed) followed by 6 mL of a mixture of diethyl ether and ethyl acetate (3:1, v / v) for liquid-liquid extraction. The mixture was vortexed for 30 s and centrifuged at 3000× g for 3 min. The organic layer was transferred into another tube ... WebSep 10, 2016 · The identification of novel pan-sigma receptor (SR) modulators, potentially useful in cancer treatment, represents a new goal of our research. Here, we report on the preparation of novel chiral compounds characterized by a 3-C alkyl chain bridging an aromatic portion to a 4-benzyl-piperidine moiety. All of the studied compounds have been …
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